Motif ID: NANOG{mouse}.p2

Z-value: 1.685


Transcription factors associated with NANOG{mouse}.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_79419940.786.1e-46Click!


Activity profile for motif NANOG{mouse}.p2.

activity profile for motif NANOG{mouse}.p2


Sorted Z-values histogram for motif NANOG{mouse}.p2

Sorted Z-values for motif NANOG{mouse}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG{mouse}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_44580870 47.903 NM_138423
NM_177974
CASC4

cancer susceptibility candidate 4

chr15_+_44580954 41.048 CASC4
cancer susceptibility candidate 4
chr16_+_640091 33.572 RAB40C
RAB40C, member RAS oncogene family
chr15_+_44581045 33.325 CASC4
cancer susceptibility candidate 4
chr16_+_640056 30.199 NM_001172665
NM_001172666
RAB40C

RAB40C, member RAS oncogene family

chr17_-_7197811 29.950 YBX2
Y box binding protein 2
chr16_+_2588051 28.097 PDPK1
3-phosphoinositide dependent protein kinase-1
chr17_-_7197896 28.016 YBX2
Y box binding protein 2
chr16_+_3096681 27.844 NM_022468
MMP25
matrix metallopeptidase 25
chr1_-_154193044 27.819 C1orf43
chromosome 1 open reading frame 43
chr17_-_7197866 27.404 NM_015982
YBX2
Y box binding protein 2
chr1_+_27719151 26.300 NM_005281
GPR3
G protein-coupled receptor 3
chr16_+_2587989 25.354 PDPK1
3-phosphoinositide dependent protein kinase-1
chr6_+_31949800 24.466 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr19_+_2096930 24.160 IZUMO4
IZUMO family member 4
chr16_+_2588000 23.858 PDPK1
3-phosphoinositide dependent protein kinase-1
chr16_+_639668 22.877 NM_001172664
RAB40C
RAB40C, member RAS oncogene family
chr9_+_124048396 21.450 GSN
gelsolin
chr9_+_137979513 21.170 OLFM1
olfactomedin 1
chr1_+_152635871 21.145 NM_178430
LCE2D
late cornified envelope 2D
chr19_+_9296269 20.720 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr16_+_640172 20.689 NM_021168
RAB40C
RAB40C, member RAS oncogene family
chr8_+_28559010 19.834 EXTL3
exostoses (multiple)-like 3
chr1_+_152647770 19.212 NM_178429
LCE2C
late cornified envelope 2C
chr17_+_7387773 19.090 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr16_+_2587951 19.060 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chr2_+_203499819 18.333 NM_173511
FAM117B
family with sequence similarity 117, member B
chr22_-_39548448 18.277 NM_175709
CBX7
chromobox homolog 7
chr9_+_124030455 18.263 GSN
gelsolin
chr8_+_22132809 17.687 NM_018068
PIWIL2
piwi-like 2 (Drosophila)
chr9_+_124030413 17.623 GSN
gelsolin
chr3_+_15469052 17.277 NM_033083
EAF1
ELL associated factor 1
chr2_-_214016332 17.251 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr19_+_35629727 17.077 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr14_+_29236882 16.952 FOXG1
forkhead box G1
chr20_-_3762060 16.807 NM_015417
SPEF1
sperm flagellar 1
chr2_+_84743576 16.660 NM_001370
DNAH6
dynein, axonemal, heavy chain 6
chr11_-_57004674 16.384 NM_005161
APLNR
apelin receptor
chr5_-_33892292 16.346 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr19_+_15218141 16.342 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr4_+_89513597 16.129 NM_014606
HERC3
hect domain and RLD 3
chr9_+_124030370 16.060 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr10_+_5566923 15.896 NM_005185
CALML3
calmodulin-like 3
chr7_+_102715580 15.475 ARMC10
armadillo repeat containing 10
chr19_+_3178735 15.252 NM_003775
S1PR4
sphingosine-1-phosphate receptor 4
chr8_+_28559143 15.248 NM_001440
EXTL3
exostoses (multiple)-like 3
chr8_+_9413390 15.194 TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr8_-_70983549 14.975 NM_024504
PRDM14
PR domain containing 14
chr19_-_54327428 14.625 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr19_-_10764449 14.469 LOC147727
uncharacterized LOC147727
chr7_-_99277518 14.032 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr22_+_26565454 13.887 SEZ6L
seizure related 6 homolog (mouse)-like
chr20_+_43991739 13.777 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 readthrough
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr9_-_99382073 13.568 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr1_+_154193294 13.558 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr13_-_73356058 13.525 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr3_+_38388288 13.479 XYLB
xylulokinase homolog (H. influenzae)
chrX_+_13671224 13.225 NM_152634
TCEANC
transcription elongation factor A (SII) N-terminal and central domain containing
chr10_-_48390873 12.812 NM_002900
RBP3
retinol binding protein 3, interstitial
chr19_+_4969123 12.711 NM_015015
KDM4B
lysine (K)-specific demethylase 4B
chr19_-_36870064 12.218 NM_020917
ZFP14
zinc finger protein 14 homolog (mouse)
chr16_-_70719854 12.218 NM_138383
MTSS1L
metastasis suppressor 1-like
chr3_-_15468981 12.190 NM_152396
METTL6
methyltransferase like 6
chr19_+_4969126 12.112 KDM4B
lysine (K)-specific demethylase 4B
chr5_+_156693051 11.689 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr2_+_45878912 11.674 NM_005400
PRKCE
protein kinase C, epsilon
chr13_-_21099914 11.608 NM_015974
CRYL1
crystallin, lambda 1
chr10_-_1034280 11.584 LOC100288619
uncharacterized LOC100288619
chr1_+_155146270 11.528 TRIM46
tripartite motif containing 46
chr19_+_51628136 11.470 NM_001198558
NM_014441
SIGLEC9

sialic acid binding Ig-like lectin 9

chr7_+_144052432 11.311 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr14_+_24837225 11.256 NM_001198965
NM_004554
NFATC4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

chr3_+_38388222 11.255 NM_005108
XYLB
xylulokinase homolog (H. influenzae)
chr16_+_30759619 11.045 NM_000294
NM_001172432
PHKG2

phosphorylase kinase, gamma 2 (testis)

chr6_+_26087447 11.042 NM_000410
NM_139003
NM_139004
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011
HFE








hemochromatosis








chr8_+_42752019 10.919 NM_032410
HOOK3
hook homolog 3 (Drosophila)
chr7_+_150549531 10.581 NM_001091
ABP1
amiloride binding protein 1 (amine oxidase (copper-containing))
chr3_+_31574119 10.543 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr3_-_139258373 10.541 RBP1
retinol binding protein 1, cellular
chr14_+_92788924 10.525 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr17_+_7388080 10.405


chr19_-_3047632 10.387 NM_001144761
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr17_-_61777467 10.373 LIMD2
LIM domain containing 2
chr2_+_64751545 10.370 AFTPH
aftiphilin
chr3_+_32148136 10.325 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr12_-_51477299 10.245 NM_030809
CSRNP2
cysteine-serine-rich nuclear protein 2
chr4_-_57522469 10.157 NM_001145459
NM_139211
HOPX

HOP homeobox

chr4_-_16077740 10.115 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr6_+_292456 10.038 DUSP22
dual specificity phosphatase 22
chr3_+_38388295 10.036 XYLB
xylulokinase homolog (H. influenzae)
chr13_-_73356070 10.018 NM_001128226
NM_014953
DIS3

DIS3 mitotic control homolog (S. cerevisiae)

chr6_+_99872769 9.952


chr17_+_45772629 9.903 NM_014726
TBKBP1
TBK1 binding protein 1
chr17_-_76573475 9.807 NM_173628
DNAH17
dynein, axonemal, heavy chain 17
chr22_+_26565623 9.750 SEZ6L
seizure related 6 homolog (mouse)-like
chr13_-_73355969 9.717 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr5_+_41925355 9.678 NM_012176
NM_033484
FBXO4

F-box protein 4

chr19_-_13213669 9.678 LYL1
lymphoblastic leukemia derived sequence 1
chr3_-_139258477 9.648 RBP1
retinol binding protein 1, cellular
chr16_+_6069094 9.600 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr20_+_36974823 9.598 NM_004139
LBP
lipopolysaccharide binding protein
chr1_+_44115828 9.574 KDM4A
lysine (K)-specific demethylase 4A
chr17_+_48172508 9.573 NM_001199900
NM_002611
NM_001199899
PDK2


pyruvate dehydrogenase kinase, isozyme 2


chrX_+_14547419 9.500 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr19_-_13213513 9.475 LYL1
lymphoblastic leukemia derived sequence 1
chr14_+_76618244 9.415 NM_017926
NM_017972
C14orf118

chromosome 14 open reading frame 118

chr17_-_43128803 9.395 NM_001128631
DCAKD
dephospho-CoA kinase domain containing
chrX_+_54556726 9.380 GNL3L
guanine nucleotide binding protein-like 3 (nucleolar)-like
chrX_+_38420690 9.306 NM_004615
TSPAN7
tetraspanin 7
chr11_-_62457001 9.301 LRRN4CL
LRRN4 C-terminal like
chr4_+_24797084 9.279 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr21_-_34863779 9.264 NM_017833
DNAJC28
DnaJ (Hsp40) homolog, subfamily C, member 28
chr13_+_73356179 9.084 NM_006346
PIBF1
progesterone immunomodulatory binding factor 1
chr3_-_38065995 9.032 PLCD1
phospholipase C, delta 1
chr19_+_39897457 9.031 NM_003407
ZFP36
zinc finger protein 36, C3H type, homolog (mouse)
chr19_+_56186569 9.014 EPN1
epsin 1
chr1_-_28520379 8.960 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr2_-_97405775 8.935 LMAN2L
lectin, mannose-binding 2-like
chr11_+_117947726 8.816 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr1_-_202129118 8.806 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr17_+_72744794 8.716 SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr13_-_45010974 8.642 TSC22D1
TSC22 domain family, member 1
chr17_+_74732629 8.626 NM_001242534
MFSD11
major facilitator superfamily domain containing 11
chr13_-_50018143 8.619 NM_001079670
CAB39L
calcium binding protein 39-like
chr13_-_45010994 8.616 TSC22D1
TSC22 domain family, member 1
chr22_+_31090792 8.571 NM_030758
OSBP2
oxysterol binding protein 2
chr11_-_2906960 8.528 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr1_+_155853546 8.390 SYT11
synaptotagmin XI
chr8_+_22133079 8.370 NM_001135721
PIWIL2
piwi-like 2 (Drosophila)
chr22_+_41487787 8.306 EP300
E1A binding protein p300
chr10_+_102891060 8.271 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr22_+_26565424 8.141 NM_001184773
NM_001184774
NM_001184775
NM_001184776
NM_001184777
NM_021115
SEZ6L





seizure related 6 homolog (mouse)-like





chr19_-_37701385 8.136 NM_152279
ZNF585B
zinc finger protein 585B
chr13_+_58205943 8.125 PCDH17
protocadherin 17
chr1_-_155145732 8.109 NM_173852
KRTCAP2
keratinocyte associated protein 2
chr14_-_91526912 8.065 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chrX_-_15872871 8.040 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr6_+_160327972 8.000 NM_002377
MAS1
MAS1 oncogene
chr14_-_23285011 7.946 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr20_+_58508818 7.936 NM_001190826
C20orf177
chromosome 20 open reading frame 177
chr16_+_31494438 7.861 NM_003041
SLC5A2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr11_-_67205151 7.848 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr16_+_29674564 7.807 SPN
sialophorin
chr9_-_86571533 7.741 C9orf64
chromosome 9 open reading frame 64
chr15_-_78526841 7.678 NM_001199377
NM_015162
ACSBG1

acyl-CoA synthetase bubblegum family member 1

chr9_-_35111534 7.588 FAM214B
family with sequence similarity 214, member B
chr7_+_150549577 7.548 ABP1
amiloride binding protein 1 (amine oxidase (copper-containing))
chr4_+_24797203 7.499 SOD3
superoxide dismutase 3, extracellular
chr17_+_27370155 7.499 PIPOX
pipecolic acid oxidase
chrX_+_140096760 7.433 NM_145664
NM_139019
NM_032461
SPANXB2
SPANXF1
SPANXB1
SPANX family, member B2
SPANX family, member F1
SPANX family, member B1
chr19_+_50381380 7.343 TBC1D17
TBC1 domain family, member 17
chr8_-_9008138 7.312 NM_024607
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr1_+_20465818 7.274 NM_022819
PLA2G2F
phospholipase A2, group IIF
chr17_+_59477473 7.258 TBX2
T-box 2
chr12_+_7942025 7.055 NANOG
Nanog homeobox
chr2_+_113033146 7.040 NM_198581
ZC3H6
zinc finger CCCH-type containing 6
chr11_-_84634437 7.009 NM_001364
DLG2
discs, large homolog 2 (Drosophila)
chr8_-_70983468 7.002 PRDM14
PR domain containing 14
chr17_+_72744802 6.939 SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr15_+_74833517 6.934 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr10_+_64133915 6.905 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr2_+_113875469 6.866 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr19_+_4304590 6.848 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr6_+_31539875 6.816 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr11_+_1940798 6.809 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr16_+_8806825 6.714 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr3_-_194991778 6.694 NM_152531
XXYLT1
xyloside xylosyltransferase 1
chr17_-_34313685 6.675 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chr2_+_74273449 6.664 NM_144993
TET3
tet methylcytosine dioxygenase 3
chr1_+_171810611 6.620 NM_001136127
NM_015569
DNM3

dynamin 3

chr11_-_72504643 6.591 NM_006645
STARD10
StAR-related lipid transfer (START) domain containing 10
chr19_+_55141907 6.516 NM_001081638
NM_001081639
NM_001081637
LILRB1


leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1


chr4_+_37455551 6.506 NM_001104629
C4orf19
chromosome 4 open reading frame 19
chr22_-_31686707 6.500 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr10_+_124220990 6.468 NM_002775
HTRA1
HtrA serine peptidase 1
chr2_+_64681610 6.449 LGALSL
lectin, galactoside-binding-like
chrX_-_134971142 6.441 NM_001017438
CT45A3
CT45A4
CT45A5
CT45A6
CT45A1
cancer/testis antigen family 45, member A3
cancer/testis antigen family 45, member A4
cancer/testis antigen family 45, member A5
cancer/testis antigen family 45, member A6
cancer/testis antigen family 45, member A1
chr3_-_16646244 6.437 NM_001190811
DAZL
deleted in azoospermia-like
chr5_+_139493689 6.384 NM_005859
PURA
purine-rich element binding protein A
chr22_-_36013303 6.375 NM_005368
NM_203378
MB

myoglobin

chr19_+_7069686 6.317 ZNF557
zinc finger protein 557
chr13_-_45010937 6.293 TSC22D1
TSC22 domain family, member 1
chr6_-_41130820 6.268 TREM2
triggering receptor expressed on myeloid cells 2
chr17_-_7518124 6.212 NM_004860
FXR2
fragile X mental retardation, autosomal homolog 2
chr11_-_2182408 6.173 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough
chr4_+_154125589 6.161 NM_015271
TRIM2
tripartite motif containing 2
chr11_-_64510339 6.152 RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr11_-_8285299 6.148 NM_002315
LMO1
LIM domain only 1 (rhombotin 1)
chr22_+_37447615 6.147 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr16_-_70719693 6.139 MTSS1L
metastasis suppressor 1-like
chr14_+_76618272 6.139 C14orf118
chromosome 14 open reading frame 118
chr10_+_86004808 6.136 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr6_-_46889620 6.059 NM_001098518
GPR116
G protein-coupled receptor 116
chr3_+_46619075 5.970 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr13_-_22033505 5.946 NM_153251
ZDHHC20
zinc finger, DHHC-type containing 20
chr9_-_73483933 5.931 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr11_+_63871240 5.910 NM_013280
FLRT1
fibronectin leucine rich transmembrane protein 1
chr22_-_51021337 5.900 NM_005198
CHKB
CHKB-CPT1B
choline kinase beta
CHKB-CPT1B readthrough (non-protein coding)
chr2_+_234160317 5.896 ATG16L1
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chrX_-_107018889 5.886 TSC22D3
TSC22 domain family, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.86 8.82e-03 GO:0030837 negative regulation of actin filament polymerization
1.35 1.90e-02 GO:0023052 signaling
1.53 2.79e-02 GO:0048583 regulation of response to stimulus
1.48 3.36e-02 GO:0065008 regulation of biological quality
2.22 3.45e-02 GO:0006873 cellular ion homeostasis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 2.17e-04 GO:0071944 cell periphery
1.36 2.90e-04 GO:0005886 plasma membrane
1.54 3.28e-04 GO:0044459 plasma membrane part
1.72 8.49e-04 GO:0005887 integral to plasma membrane
1.69 1.67e-03 GO:0031226 intrinsic to plasma membrane

Nothing significant found in function category.